I was diagnosed with Stage 3 PBC and Mesenteric Panniculitis in March. I found out I have Hashimotos about 10 years ago. I also suddenly developed high blood pressure last year. Hashis caused me to gain 100 pounds, have joint pain, cold intolerance, extreme fatigue, insomnia and migraine headaches. Since starting a GLP-1, about 7 months ago, I'm down 57 pounds and my symptoms have improved so much! My TSH is normal all the time now. I don't really have any physical symptoms of PBC yet, except maybe fatigue; but my doctor told me he thinks being on the GLP-1 may have kept my liver from getting worse.